How frequently must the IRB conduct continuing review of an approved protocol?

The correct answer is that the IRB (Institutional Review Board) must conduct continuing review of an approved protocol at least annually. This requirement is grounded in ethical standards and regulatory compliance aimed at protecting the rights and welfare of research participants.

Annual reviews ensure that the IRB can monitor ongoing research for any emerging risks, changes in the study protocol, or issues that may arise during the course of the research. This ongoing oversight is essential in maintaining the safety of participants and ensuring that the research continues to meet ethical standards.

Other timeframes provided in the choices, such as every six months, every two years, or every three years, do not fulfill the federal regulatory requirements that mandate at least an annual review. This annual requirement reinforces the commitment to participant safety and ethical integrity throughout the research process.